Study of Cell Orientation Alignment in Response to Cyclic Mechanical Stresses

http://deepblue.lib.umich.edu/bitstream/2027.42/96985/1/UMURF-Issue06_2009-AAhmed.pd

Peripheral T-cell lymphoma presenting as testicular mass; a diagnostic challenge

Background: T-cell lymphomas involve the testis infrequently, which deserve special attention because of the poor prognosis and the need to make an appropriate diagnosis, which could lead to a better therapeutic strategy.Case Presentation: A 40-year-old man presented with right testicular swelling for past three months. The swelling was painless, hard and rubbery. Testicular ultrasound showed diffuse increase in size of the testicle, with alteration in its echogenicity. The patient underwent orchidectomy, and based on histopathological and immunohistochemical tests, a peripheral T-cell lymphoma, not otherwise specified was diagnosed.Conclusion: Testicular peripheral T-cell lymphomas are rare and aggressive cancers, with clinical differentials of seminoma and non-neoplastic conditions

Leveraging intelligence from network CDR data for interference aware energy consumption minimization

Cell densification is being perceived as the panacea for the imminent capacity crunch. However, high aggregated energy consumption and increased inter-cell interference (ICI) caused by densification, remain the two long-standing problems. We propose a novel network orchestration solution for simultaneously minimizing energy consumption and ICI in ultra-dense 5G networks. The proposed solution builds on a big data analysis of over 10 million CDRs from a real network that shows there exists strong spatio-temporal predictability in real network traffic patterns. Leveraging this we develop a novel scheme to pro-actively schedule radio resources and small cell sleep cycles yielding substantial energy savings and reduced ICI, without compromising the users QoS. This scheme is derived by formulating a joint Energy Consumption and ICI minimization problem and solving it through a combination of linear binary integer programming, and progressive analysis based heuristic algorithm. Evaluations using: 1) a HetNet deployment designed for Milan city where big data analytics are used on real CDRs data from the Telecom Italia network to model traffic patterns, 2) NS-3 based Monte-Carlo simulations with synthetic Poisson traffic show that, compared to full frequency reuse and always on approach, in best case, proposed scheme can reduce energy consumption in HetNets to 1/8th while providing same or better Qo

A SON Solution for Sleeping Cell Detection Using Low-Dimensional Embedding of MDT Measurements

Automatic detection of cells which are in outage has been identified as one of the key use cases for Self Organizing Networks (SON) for emerging and future generations of cellular systems. A special case of cell outage, referred to as Sleeping Cell (SC) remains particularly challenging to detect in state of the art SON because in this case cell goes into outage or may perform poorly without triggering an alarm for Operation and Maintenance (O&M) entity. Consequently, no SON compensation function can be launched unless SC situation is detected via drive tests or through complaints registered by the affected customers. In this paper, we present a novel solution to address this problem that makes use of minimization of drive test (MDT) measurements recently standardized by 3GPP and NGMN. To overcome the processing complexity challenge, the MDT measurements are projected to a low-dimensional space using multidimensional scaling method. Then we apply state of the art k-nearest neighbor and local outlier factor based anomaly detection models together with pre-processed MDT measurements to profile the network behaviour and to detect SC. Our numerical results show that our proposed solution can automate the SC detection process with 93 accuracy

Effects of Sofosbuvir on Serum Lipid Profile and Serum Uric Acid in Albino Rats

Objective: To determine the effects of sofosbuvir over serum lipid profile and serum uric acid level in albino rats.Study Design: Experimental interventional DesignSetting: Department of Pharmacology Isra University Hyderabad and Department of animal husbandry, Sindh Agriculture University Tandojam.Study Duration: 6 months following synopsis approval.Sampling techniques:  Non probability purposive samplingSample Size:  40 Albino Rats weighing 200-300gm on averageMethodology: Rats were selected based on inclusion and excluding criteria. Rats were divided into 4 equal groups control, A, B and C each having 10 rats. Control group was given Normal saline, powdered milk, and flour. A, B and C were treated with Sofosbuvir dose 5.7 mg/kg, 11.4 mg/kg, 17.0 mg/kg respectively. Blood samples were collected at day 1 before starting the treatment and then at the end of the study (after 6 weeks) by sacrifying the rats under international protocols. Blood samples were analysed for serum uric acid and lipid profile. Results: There were significant changes in the total cholesterol between control and experimental group C, p-value 0.05, while no significant difference was noted between control and experimental group A and B. These findings show that the high dose of sofosbuvir drug changed the total cholesterol level. LDL showed a significant elevation in the experimental groups as compared to control with uses of sofosbuvir drug, the elevated difference was noted as in experimental groups A  P value = 0.006, similarly in group B  p- value 0.008 and in group C  p- value 0.008. No significant effects were found in TG and HDL levels in all experimental groups with controls. A significant difference was noted in the reduction of uric acid level between control and experimental group B and Experimental Group C, p- values were quite significant.Conclusion: It was concluded that serum uric acid was significantly decreased; LDL and total cholesterol were elevated with use of sofosbuvir drug

Evaluation of Growth of Different Maize Varieties in Field under the Climatic Conditions of Peshawar

A field experiment on “Evaluation of maize varieties under the climatic condition of Peshawar” was conducted at Agricultural Research Institute Tarnab (ARI) during Kharif season 2012. The experiment was conducted in Randomized Complete block Design (RCB). emergence was non significant those plot sown with Iqbal taken maximum days to emergence of (7) days while plot sown with pop-2011 taken minimum days to emergence of (4) days . Higher emergence ­­­­­m­-²(8) was recorded for pop-08 and Jalal showed lowest (3) emergence ­­­­­m­-².   Jalal took (53) days to tasseling while Pir sabaq evaluation showed the lowest (46) days to tasseling among the different maize varieties. Analysis of the data indicated that days to silking were significantly affected by maize varieties. Minimum (52) days to silking were observed in pop-2011 while maximum (56) days to silking were observed in Sarhad white.Lowest plant height was observed in jalal (160 cm) while highest plant height was recorded  in pop-07 (184 cm). Different varieties have different plant height, lowest cob height was observed in jalal (48 cm) while highest cob height was recorded in pop-09 (66 cm). Minimum (76) days to physiological were observed in pop-2011 while maximum (81) days to physiological maturity were observed in Sarhad white. Minimum (90) days to harvest maturity were observed in pop-2011 while maximum (97) days to harvest maturity were observed in Sarhad white. maximum 1000 grain weight was recorded for pop-2011 (275 g) while minimum 1000 grain weight was recorded for Iqbal (227 g).Statistical analysis of the data revealed that the data for grain yield was significant those plot sown with Jalal have the minimum grain yield of (1500 kgha-1) while plot sown with pop-2011 have the maximum grain yield of (4666 kg ha-1). Keywords: Maize, Emergence, Days to Maturity, Grain yield, Harvest, Analysi

Is it really transverse myelitis? Acute flaccid Myelitis a rare entity.

Acute Flaccid Myelitis is a relatively new and rare disease entity which was recognized for the first time in United States in 20121. Usually children below 18 years of age present with sudden onset rapidly progressive flaccid paralysis sometimes following upper respiratory tract infection. To date no cases have been reported from Afghanistan and Pakistan. We are reporting case of a young girl who presented with sudden onset flaccid paralysis and respiratory distress. Her MRI Cervical spine showed longitudinally extensive transverse myelitis. One year after the onset of disease flaccid paraparesis continued despite various treatments. It is important to report cases of acute flaccid myelitis as it is a new disease with poor prognosis. People including clinicians are not aware of it

Effect of aescin on β-cell physiology in fructose fed rat model

Objective: To determine the effects of Aescin on blood glucose homeostasis in fructose fed Diabetic albino Wistar rats Methodology: This Quasi Experimental study was conducted at the Department of Physiology from July 2018 to January 2019. Sixty albino (Wistar) rats were equally divided into five groups according to diet as; Group A (normal diet) and Group B (Fructose 10 g/kg/day) and all the other experimental groups were given Fructose (10 g/kg/day) with the administration of aescin as; Group C (0.9 mg/kg/day), Group D (1.8 mg/kg/day) and Group E (3.6 mg/kg/day). After four weeks body weight was calculated and blood samples were taken from all animals to assess the blood glucose level and serum insulin level. All the data was recorded in self-made proforma. Results: Mean of blood glucose in control group A (165.0±14.29 mg/dL) was significantly lower in contrast to experimental groups B, C and D (357.17±21.73, 246.08±21.73 and 235.67±25.73 respectively); p-0.001, while the mean difference was insignificant as compared to experimental group E (194.0±22.16 mg/dl); p=0.078. Serum insulin level was significantly lower in experimental group B (17.45± 5.17) as compared to control group A (16.88± 4.78); p-0.001, while Aescin administered groups C and D showed serum insulin level (19.05± 5.81 and 25.08± 2.42 respectively) almost equal to control group A; p-0.092. Mean serum insulin level in Aescin (3.6 mg/kg/day) administrated group E was significantly higher (29.10± 1.64 IU/L) as compared control and other experimental groups; p-0.001. Conclusion: The Aescin showed exerts ameliorating effects on glucose homeostasis in fructose fed Diabetic albino Wistar rats. By Aescin administration, serum insulin level can be increases to control the diabetes

Primary non-functioning paraganglioma of liver: A rare tumour at an unusual location

Pheochromocytomas are rare tumours, 22% of which are extra-adrenal and are known as paragangliomas. We report a case of a young male with non-functioning paraganglioma of the liver; a very uncommon primary site. A CT scan with contrast showed a huge, highly vascular mass lesion in the right lobe of the liver and a core biopsy confirmed it to be a paraganglioma. Whole body study with iodine-131-meta-iodobenzylguanidine (MIBG) tracer highlighted the liver tumour but was negative for any other active lesions depicting that the tumour was confined to the liver. The lesion was completely resected by extended right hepatectomy and the patient had an uneventful recovery. There is no evidence of disease recurrence at 3 years of follow up